ABSTRACT
Irrespective of progressive treatments, cancer remains to have the utmost rate of treatment failure due to numerous reasons associated. In recent years, the use of traditional medicine in cancer research has established considerable interest. Natural products represent an amazing source for cancer therapy and combating associated side-effects. More than thousand plants have been found to possess significant anticancer properties. Vitex is the largest genus in the family Lamiaceae which comprises 250 species distributed throughout world and several species have been reported to have anticancer properties. Despite a long tradition of use of some species, the genus has not been explored properly in terms of its anticancer profile. Here we are reporting the updated knowledge of the antineoplastic profile of this genus available so far. In the concluding part, the future scope of Vitex species has been emphasized with a view to explore its multifarious antineoplastic activities and mode of action.
Independientemente de los tratamientos progresivos, el caÌncer sigue teniendo la mayor tasa de fracaso del tratamiento debido a numerosas razones asociadas. En los uÌltimos anÌos, el uso de la medicina tradicional en la investigacioÌn del caÌncer ha despertado un gran intereÌs. Los productos naturales representan una fuente increiÌble para la terapia contra el caÌncer y la lucha contra los efectos secundarios asociados. Se han encontrado maÌs de mil plantas que poseen propiedades anticanceriÌgenas significativas. Vitex es el geÌnero maÌs grande de la familia Lamiaceae, que comprende 250 especies distribuidas en todo el mundo y se ha informado que varias especies tienen propiedades anticanceriÌgenas. A pesar de una larga tradicioÌn de uso de algunas especies, el geÌnero no ha sido explorado adecuadamente en teÌrminos de su perfil contra el caÌncer. AquiÌ presentamos el conocimiento actualizado del perfil antineoplaÌsico de este geÌnero disponible hasta el momento. En la parte final, se ha enfatizado el alcance futuro de las especies de Vitex con el objetivo de explorar sus muÌltiples actividades antineoplaÌsicas y su modo de accioÌn.
Subject(s)
Vitex/chemistry , Plant Preparations/chemistry , Phytochemicals , Antineoplastic Agents/chemistryABSTRACT
Objective:To prepare and evaluate a herbal antioxidant face cream which is made by the ethanol extract of Nardostachys jatamansi (Valerianceae). Methods: Antioxidant activity of ethanol extract was assessed by previously reported 2, 2-Diphenyl-1-picrylhydrazyl method. By discovering different types of formulations, such as oil in water, we were able to create several face creams respectively classified from F1 to F6, by incorporating different concentrations of stearic acid and acetyl alcohol. The evaluation of all formulations (F1 to F6) has been done by the analysis of different parameters like pH, viscosity, spread ability and stability. Results: An ethanol fraction analyzed from a sample of Nardostachys jatamansi showed a significant antioxidant activity with an IC50 value of 58.39 μg/mL while for ascorbic acid the IC50 value was 46.68 μg/mL. Among the six formulations (F1-F6) F5 and F6 showed good spread ability, good consistency, homogeneity, appearance, pH;there is no proof of a separation phase and ease of removal. Also the formulations F5 and F6 showed no redness or edema or erythema and irritation during irritancy studies. Conclusions:These formulations can be safely used on the skin. Hence, the study suggests that the composition of extract and the base of the cream F5 and F6 are more stable and safe, but it may produce synergistic action.